HES 130/0.4, a new HES specification: tissue storage after multiple infusions in rats

Pediatric hypereosinophilic syndrome (HES) differs from adult HES.

The idiopathic hypereosinophilic syndrome (HES) developed in a 15-year-old boy who presented with colitis, cough, rash, and hepatitis. Molecular analysis failed to demonstrate the Fip1-like1-Platelet Derived Growth Factor Receptor alpha chain (FIP1L1-PDGFRA) mutation described in adult patients with HES. There are significant clinical differences between the pediatric and adult presentations of...

Recombination in hES cells

The study of protein structure and function is often greatly facilitated by the introduction of various biophysical probes directly onto the protein of interest. Though recombinant and cell-free expression systems for incorporating probes are rapidly developing, chemical methods of probe introduction are now robust and valuable technologies. Muralidharan and Muir present a practical guide for u...

A Study of Approa hes to

Comparison of HES 130/0.42 and HES 200/0.5 for hemodynamic stabilisation in major urological surgery

Purpose: Different hydroxyethyl starches (HES) may lead to different volume effects. We compared a new HES130/0.42 with an established HES200/0.5 with respect to perioperative volume requirements, hemodynamic effects, safety and tolerability. Methods: After approval of the local ethics committee we investigated in a prospective, randomized double-blinded clinical trial 100 adult patients schedu...

Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

The transcription factor ISL1 is thought to be key for conveying the multipotent and proliferative properties of cardiac precursor cells. Here, we investigate its function upon cardiac induction of human embryonic stem cells. We find that ISL1 does not stabilize the transient cardiac precursor cell state but rather serves to accelerate cardiomyocyte differentiation. Conversely, ISL1 depletion d...